BackgroundCommentators believe that the ethical decision-making climate is instrumental in enhancing interprofessional collaboration in intensive care units. Our aim was twofold: to determine the perception of the ethical climate, levels of moral distress, and intention to leave one's job among nurses and physicians, and between the different ICU types and determine the association between the ethical climate, moral distress, and intention to leave.MethodsWe performed a cross-sectional questionnaire study between May 2021 and August 2021 involving 206 nurses and physicians in a (...) large urban academic hospital. We used the validated Ethical Decision-Making Climate Questionnaire and the Measure of Moral Distress for Healthcare Professionals tools and asked respondents their intention to leave their jobs. We also made comparisons between the different ICU types. We used Pearson's correlation coefficient to identify statistically significant associations between the Ethical Climate, Moral Distress, and Intention to Leave.ResultsNurses perceived the ethical climate for decision-making as less favorable than physicians. They also had significantly greater levels of moral distress and higher intention to leave their job rates than physicians. Regarding the ICU types, the Neonatal/pediatric unit had a significantly higher overall ethical climate score than the Medical and Surgical units and also demonstrated lower moral distress scores and lower “intention to leave” scores compared with both the Medical and Surgical units. The ethical climate and moral distress scores were negatively correlated ; moral distress and "intention to leave" was positively correlated ; and ethical climate and “intention to leave” were negatively correlated.ConclusionsSignificant differences exist in the perception of the ethical climate, levels of moral distress, and intention to leave between nurses and physicians and between the different ICU types. Inspecting the individual factors of the ethical climate and moral distress tools can help hospital leadership target organizational factors that improve interprofessional collaboration, lessening moral distress, decreasing turnover, and improved patient care. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

This book offers the first sustained, full-length treatment of the wide-ranging work of major Anglican theologian Oliver O'Donovan. Analysing key texts written across forty years, including Resurrection and Moral Order, The Desire of the Nations, and Ethics as Theology, Samuel Tranter focuses in particular on what he argues is an area of real tension in O'Donovan's evolving vision of moral theology: the relationship between eschatology and ethics. This tension is traced as it plays out with regard to a number (...) of important topics in O'Donovan's writing and contemporary discussion, including natural law, divine command, and human flourishing, as well as the distinctiveness or otherwise of Christian moral reasoning. Moreover, it is located alongside the broader doctrinal features of O'Donovan's project, in connection to themes such as creation, sin, and redemption, as well as to particular questions about the relationship between the cross and the resurrection. This volume also advances the reception of O'Donovan's thought by establishing and evaluating his influence upon a range of Christian ethicists and political theologians writing today (such as Luke Bretherton, Gilbert Meilaender, Jean Porter, and Brent Waters), and by engaging with critical readings of O'Donovan (such as those by Stanley Hauerwas and Gerald McKenny). Furthermore, in conversation with these scholars among an ecumenical cast of voices, Tranter offers an assessment of how O'Donovan's proposals may be appropriated and amended as a resource for theology and ethics going forward. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:"Spirituality":"Weasel-Word" or Gateway to New Understanding?Peter Gilbert (bio)Keywordsspirituality, faith communities, NIMHEVisiting the Samuel Palmer Exhibition at the British Museum, I was struck, not only by the spiritual power of the paintings, especially in the late Shoreham period such as, my favorite: The Magic Apple Tree (circa 1830)—but how Palmer appeared to bring both Christian and Pantheistic themes into his work. The museum's exhibition collator remarks that Palmer (...) saw the fruitfulness of the earth as an intimation of Divine creativity. The artist sought to capture "The essential vivifying spirit, vital spark" (Palmer's words) of the physical world in which we live.I was reminded as I moved from The Magic Apple Tree, to In a Shoreham Garden, and The Golden Valley, how these paintings had been used by a record company when they had issued all of Ralph Vaughan Williams' orchestral and choral works in the 1970s, to mark his anniversary. Vaughan Williams was not a signed up Christian, but many of his choral works express a strong yearning for the transcendent using Christian imagery. The day before I visited the Palmer exhibition, I listened to Professor Robert Winston on Start the Week (28th November, 2005), in which he spoke of his BBC series The Story of God (Winston, 2005). As a scientist, Winston is intrigued as to why humans seek the transcendent. He continually refers to this desired other as "God," although I think it would be more accurate to call it a search for the transcendent. Winston puzzles over why there appears to be "a God-shaped hole" within humanity (Start the Week, November, 28, 2005), and again, as a scientist, postulates that: "the more we understand about science, the less we understand about the Universe."In the light of the most popular films and books at present, the search for something beyond ourselves appears to be very much at the center, rather than at the periphery of humanity's consciousness at the present time. Reading Philip Pullman's His Dark Materials trilogy, and reading his various essays, we are struck by his articulation of the human search:We need a story, a myth that does what the traditional religious stories did. It must explain. It must satisfy our hunger for a Why... There are two kinds of Why, and our story must deal with both. There's the one that asks What brought us here? and the other that asks What are we here for?(Pullman, 2001)The author's article is very helpful in its practical approach to psychotherapy and spirituality. I particularly liked her reference to the work of Charles Corr (1991) and his work with people [End Page 197] who are dying and considering the physical, psychological, social, and spiritual aspects of the last days. The spiritual aspects being around identifying, developing, or reaffirming spiritual sources of energy and hope. This is the kind of approach that the National Institute for Mental Health in England (NIMHE) national Project on Spirituality and Mental Health has been engaged in since 2001, the approach being to stress the spiritual dimension as an integral part of a whole person and whole systems approach to mental health; work with mental health services and their partners to engage with this agenda; and work toward a better understanding between faith communities and mental health services (see Gilbert and Nicholls, 2003). Service users and their carers are increasingly stating strongly to services that they wish to have their spiritual dimension and spiritual needs addressed properly—and certainly not in a "tick-box" method! The author quotes Samson and Zerter (2003) as saying that the person's spiritual dimension "draws a thread of identity, relationship, meaning and purpose, which weave through each of these aspects" (i.e. the life events and other aspects of their being).I welcome the author's stress on a "relational approach," and her breadth of reference, for example, the diary of Marcus Aurelius, the Roman emperor and philosopher, but I had some concerns about her use of the term personal theology, and talk of the personal aspect of religion and "the Divine," in that I think that this could... (shrink)

This paper takes a philosophical look at how the views of Gilbert Ryle and Kwasi Wiredu can be used to resolving the mind-body problem located in Rene Descartes’ philosophy. The common sense account of the mind-body theory was first systematically carried out by Descartes. To him, mind and body do not only exist, they also interact. Through his notion of clear and distinct ideas, Descartes infers the existence of the mind as a thinking substance. Unlike the mind, whose character (...) is thought, the body for Descartes is an extended thing. He insists that the point of interaction is the pineal grand, which God has worked out from the point of creation. Today, the view that body and mind interact has generated some controversies. Ryle argues that Descartes has made a category mistake by interpreting mind as a distinct substance. For Wiredu, in Akan thought system, mind does not go to constitute a person. Thus Ryle and Wiredu tend toward materialism when they argue that the source of consciousness is the brain, rather than the mind. This paper explores the claims of these philosophers: Descartes, Ryle and Wiredu. I stress that Ryle and Wiredu’s views do not resolve the Cartesian problem. The paper concludes that unless the problem of the source of consciousness is tackled, the mind-body problem cannot be adequately resolved. (shrink)

Though not meant as a practical procedure, it can help our thinking about language and the mind if we ask what would be involved in interpreting someone's words and actions. Moreover, if we imagine ourselves beginning this interpretative process without any prior knowledge of what the person means by her words or what propositional attitudes she has, then we are engaged in what is called ‘radical interpretation’, quine originally discussed the idea of radical translation in respect of another's language and (...) Davidson, generalizing on this so that interpretation and not merely translation is at issue, has made this notion central to his account of the mind. (See also rationality.). (shrink)

This paper takes a new look at Francis Hutcheson's moral sense theory and examines it in light of the views of his rationalist critics and opponents who claim that there has to be an antecedent moral standard prior to any sense or affections. I examine how Gilbert Burnet, Samuel Clarke, and Catharine Trotter Cockburn each argue for the priority of reason over a moral sense and how Hutcheson responds or could respond to their views. Furthermore, I consider the (...) proposal that rather than regarding Hutcheson's moral sense theory as fundamentally opposed to moral rationalism, Hutcheson and Clarke endorse a shared moral metaphysics, as argued by Patricia Sheridan. Although I consider this proposal as too broad and believe it overlooks relevant metaphysical differences between Clarke and Hutcheson, I argue that the dispute between Hutcheson and his critics and opponents will not be settled without taking their underlying moral metaphysics into consideration. (shrink)

The correspondence between Samuel Clarke and Anthony Collins of 1706–8, while not well known, is a spectacularly good debate between a dualist and a materialist over the possibility of giving a materialist account of consciousness and personal identity. This article puts the Clarke Collins Correspondence in a broader context in which it can be better appreciated, noting that it is really a debate between John Locke and Anthony Collins on one hand, and Samuel Clarke and Joseph Butler on (...) the other. Anthony Collins argues on behalf of John Locke's claim that it would be as easy for God to superadd the power of thinking to matter as for him to connect a soul to a body. Locke did not believe that matter could naturally produce thought or consciousness, but it was in God's power to make matter think. To defend Locke's claim Collins must defend the claim that there are emergent properties in the world – properties of a whole that are not possessed by the parts. Collins also defends a materialist version of Locke's account of personal identity against a variety of charges. Because the topics of debate in the correspondence are of such great interest to us, it deserves to be rescued from the neglect into which it fell and from which intellectual historians and philosophers have only recently and partially removed it. (shrink)

_ Source: _Volume 25, Issue 1, pp 72 - 94 Politics has never been considered Martin Buber’s forte. This paper considers the range of Buber’s reception as a political thinker by considering it in the form of three “moments,” each from a different point in his career, and each through the eyes of a different figure who either read or worked with Buber politically: Theodor Herzl, Gustav Landauer, and Hans Kohn. The three moments are structured around a discussion of the (...) classic criticism that Buber’s politics are naïve or utopian; the paper seeks to respond, as Buber did, in a way that raises questions about the borders of politics itself. (shrink)

This book is intended for Prizes won etc.

James Wetzel offers a philosophical reformulation of the doctrine of original sin. In this response I explore the subtleties of his account and question whether his reformulation has not lost something-crucial the connection of original sin and God's grace enacted in Jesus.

Este trabajo tiene como propósito aportar algunos elementos para una reflexión sobre los procesos de industrialización en la provincia de Catamarca - Argentina en la segunda mitad del siglo XIX. Para orientarnos en esta dirección partiremos del proyecto de una enciclopedia genética propuesta por el filósofo Gilbert Simondon cómo propuesta de abordaje. Luego analizaremos el espíritu enciclopédico presente en los escritos económicos de Federico Schickendantz y Samuel Lafone Quevedo estructurados como máquinas de enseñar. Por último, presentaremos la descripción (...) de dos objetos técnicos creados por el D. Mardoqueo Molina y Bazán elaborada en estos escritos. Consideramos que estos objetos técnico aportaron un paradigma de inteligibilidad para la construcción de ciertas imágenes del porvenir de la actividad industrial en la provincia de Catamarca en estos escritos. Desde nuestra perspectiva, la falta de una estado metaestable a nivel social, necesario para amplificar estas imágenes del provenir, impidieron el desarrollo de una mentalidad técnica. (shrink)

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation in patients with Major Depressive Disorder.Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory. Associations between depression changes on BDI13 domains, treatment arm, (...) time, and clinical variables were tested in a mixed linear model.Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI13 were personality disorders, a past history of suicide attempt, age under 65 years old, and female sex.Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt. (shrink)

In this collection of essays, Max Black has brought together discussions on the language of politics, religion, poetry, law, and even magic. The scholars represented include W. B. Gallie, Aldous Huxley, Gilbert Ryle, Friedrich Waismann, Alan S. C. Ross, Bronislaw Malinowski, Owen Barfield, Samuel Butler, and C. S. Lewis. The selected essays deal with the danger, the power, and the extraordinary versatility of language, and show how "all of us can get our thoughts entangled in metaphors.".

We define self-control as an individual's efforts to bias the outcome of present or anticipated motivational conflicts in order to increase the likelihood that subsequent behavior serves perceived long-term interests. We suggest suppression and resolve are not “mechanisms” that underlie self-control, but rather are classes of strategies that influence motivations in order to increase the likelihood of successful self-control outcomes.

This book argues that analytical legal naturalism, which avoids the arbitrary principles associated with legal positivism and the odd properties associated with natural law, is a superior alternative for solving hard legal cases, where no close precedent arises or where conflicting precedents seem relevant.

I am writing on moral knowledge in Locke's Essay Concerning Human Understanding. There are two basic parts. In the first part, I articulate and attack a predominant interpretation of the Essay . This interpretation attributes to Locke the view that he did not write in the Essay anything that would be inconsistent with his early views in the Questions Concerning the Laws of Nature that there exists a single, ultimate, moral standard, i.e., the Law of Nature. For example, John Colman, (...) in his book John Locke's Moral Philosophy , argues that even though Locke explains in the Essay that we arbitrarily create our moral notions, they are still objective since they are bound together with the Law of Nature. Colman explains that the features of human nature relevant to the derivation of the Law of Nature are universally shared needs and concerns . I argue that this presupposes a view of Locke which assumes that there are essences of species independent of our beliefs about them. However, I attempt to show from the text of the Essay that this view cannot be supported. ;In the second part, I argue that the text of the Essay supports two alternative theses. The first is that given the kind of metaphysical world-view presupposed by the corpuscular method of science employed within the Essay, coupled with Locke's commitment to the possibility of moral knowledge, he was left with only one option with reference to ethics, viz., to make moral goodness or evil a mind-dependent relation between a rule and an action, instead of a property of an action or person which exists independently of our moral beliefs. This view is logically inconsistent with the existence of the Law of Nature. The second is that Locke has a semantical view of moral claims which is consistent with his relational view of moral goodness, viz., the primary function of moral judgments is to recommend behavior for ourselves and others. I described. However, Locke explains in the Essay that the opposite takes place with respect to our moral notions: events and persons must conform to the moral notion. ;On the account that I offer, Locke's views on moral epistemology are much closer to David Hume's than many have supposed, and correspondingly, anticipate the more skeptical views of moral epistemology in the twentieth century. (shrink)